Mouse Study Shows Potential of Bexarotene to Eradicate Beta Amyloid Plaque and Reverse Alzheimer’s Symptoms

In February 2012, researchers at Case Western University revealed results from a study using the anti-cancer drug bexarotene (brand name Tagretin) in mice that investigated what the drug would do to mice suffering from the equivalent of Alzheimer’s Disease. In particular, the study examined the impact on the amyloid beta proteins in the brains of the mice. To the surprise of the researchers, after about three days of treatment the mice recovered much if not most of their normal brain function as shown by improved behavior and cognition. Measurements of the amyloid beta plaque area in the brains showed a reduction of more than 50%. Given this, it appears bexarotene can rapidly reverse one of the main biochemical features of Alzheimer’s and reverse much of the behavioral and cognitive deficits, too.

Bexarotene was approved by the US FDA as a drug for treating cancer in 1999, so toxicity and side effects are already fairly well understood. If the drug can work similarly at fighting Alzheimer’s in humans, something that has not yet been established, it could become a short-term blockbuster drug for its owner, Japanese pharmaceutical company Eisai. And with the bexarotene patents set to expire in 2016, if it works safely it may become an affordable means to help prevent Alzheimer’s Disease within the next decade.

While these results are really exciting for people with a family history of Alzheimer’s, it’s important to note that nobody knows what the effective dosage is for this use of bexarotene. Rsearchers are hoping to have a small human trial underway within a few months to help determine dosages necessary for effectiveness against the amyloid beta plaque in human brains. They caution that mouse models of Alzheimer’s have often shown to be reversible with other drugs but the effects were not as potent in humans.
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Curcumin and the MAO Inhibitor “Cheese Effect” from Tyramine Triggered Hypertension

Curcumin is a widely consumed component of the spice tumeric, commonly used in India and other parts of Asia. One of its important properties is functioning as MAO-A (Monoamine oxidase A) inhibitor that may help with certain neurotransmitter imbalance conditions that often manifest in a diagnosis such as depression. Some research shows that MAO-A levels in the brain are higher in many people with major depression and sleep disorders. This is probably why MAO inhibitor drugs have often been helpful for such conditions.

As an inhibitor, curcumin can lower MAO-A levels. Curcumin also helps boost serotonin and dopamine levels and that may be another part of why it helps depressed people.

A reader recently wrote to me wondering if curcumin could cause the deadly “cheese effect” known as the tyramine hypertensive crisis. This is a massive spike in blood pressure that is precipitated by MAO inhibitors when consumed with many common foods, particularly cheese but also chocolate, alcohol, yogurt, tofu, soy sauce, and also many meat products such as liver, pickled meats, and pork. The full list of foods containing substantial tyramine is very long. So the question is a good one as a tyramine crisis could kill you and it is very hard to avoid tyramine in food.

I’ll approach this question from two angles. The first is the theoretical basis of why curcumin is unlikely to cause a tyramine crisis. The second is my personal experience using curcumin. But first, let me explain the tyramine crisis.

Tyramine Crisis

Tyramine is a normal breakdown product of the amino acid tyrosine. The MAO-A and MAO-B enzymes are involved in breaking down tyramine so its levels do not build up too high. When tyramine levels get too high, stored monoamines such as dopamine, norepinephrine, and epinephrine are released to an unhealthy degree. This can send blood pressure skyrocketing. Often the first symptom is a headache. When it’s really severe, it can cause organ damage such as lethal brain hemorrhaging.
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Carbohydrate Binge Eating and Weight Gain May Indicate Tryptophan and Serotonin Deficiencies

During the holiday season, you may have found yourself eating more cookies, cakes, breads, and other delicious baked goods than usual. You wouldn’t be the only one. But if polishing off a box of cereal solo, eating half a quart of ice cream, or gobbling down a whole bag of cookies is a common problem for you, consider that you may be suffering from a deficiency in your brain’s level of serotonin.

Serotonin is often spoken of as a “feel good” neurotransmitter due to low levels being correlated with symptoms of depression. Your body needs lots of tryptophan, an essential amino acid that the body cannot make on its own, to convert first into 5HTP and then into serotonin. When it does not have enough serotonin, the body may encourage you to engage in unhealthy behaviors such as carbohydrate binging because this helps raise the levels of serotonin in the brain.

You should also consider that serotonin deficiency can be a direct result in inadequate intake of proteins and particularly the amino acid tryptophan. Tryptophan deficiencies are surprisingly common in people who fail to eat enough protein and/or have protein digestion problems such as happens when they are getting older and have low stomach acid levels or were unwisely prescribed acid reflux medications. Stomach acid is crucial to unraveling tight spirals of proteins so that digestive enzymes can get in and clip them up into component amino acids that can be properly absorbed in the digestive tract.

People often inadvertently learn to engage in unhealthy behaviors such as carbohydrate binging and illegal drug use because they notice, often at a subconscious level, that it makes them feel better. Often it does this because there’s an adverse condition such as an amino acid, hormone, or neurotransmitter deficiency that has gone undiagnosed and untreated.

Some people may have caused such problems for themselves when they tried acid reflux medications that impaired their protein digestion or repeated attempts at low-calorie diets that featured inadequate levels of proteins. Such diets often deplete the body’s reserves of tryptophan and other important amino acids. Other people may have health problems such as poor protein digestion that create a tryptophan deficiency and therefore also a serotonin deficiency.

Unhealthy cycles of dieting and carb binging are particularly likely to produce tryptophan deficiencies because the dieting phase tends to deplete the body of adequate protein and then the carb binging masks the problem to some degree.
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Supplements That Can Aid Warfarin Users By Reducing Abnormal Clotting and Bleeding Risks

In my previous article Widely Used Anticoagulation Drug Warfarin (Coumadin) More Dangerous Than Commonly Thought, I discussed some coagulation disorders in which the widely prescribed drug warfarin (Coumadin) is used and how it has some very bad long-term side effects. Warfarin fails to fully solve the problem of abnormal clotting particularly in patients who have been taking it for years in whom it may actually aggravate several processes which can increase abnormal blood clotting risk.

Abnormal clotting can show up as DVTs (deep vein thrombosis which typically present as a swelling and painful leg changing colors and feeling warmer than usual), heart attacks, pulmonary embolisms (which are often lethal and the symptoms of which may be confused with a heart attack), strokes, and a variety of less frequent but still dangerous conditions. Warfarin users in some ways are more likely to have these problems if for no other reason than the warfarin interacts with vitamin K levels in a way that can often be difficult to control without additional measures.

Warfarin probably is a reasonable stop-gap measure for treating people at elevated clotting risk, but I personally do not believe it should be used for more than a few weeks on its own without also introducing a variety of other measures designed to help prevent clots. Past experience of many patients using warfarin is that they are much more likely to experience abnormal bleeding and still have abnormal clotting even when taking warfarin precisely because it is highly sensitive to vitamin K in the diet and it only modifies two blood clotting factors, prothrombin (Factor II) and Factor VII, while doing nothing to a myriad other biochemical factors that influence clot development and progression.

For many patients using warfarin, even those with genetic risk factors such as Factor V Leiden, it should be possible over a period of a year or more to eliminate the drug and its dangerous side effects. Careful monitoring of test results, consistent use of supplements that reduce a wide range of clotting risk factors, and for many people some diet changes (particularly reducing carbohydrates) are all necessary for this to be safe and successful.

Unfortunately, not all warfarin patients are candidates for stopping the drug. Dr. William Davis, a cardiologist who often advises the use of supplements over prescription drugs, says that those with artificial heart valve replacements are likely to need to continue to take the drug because their clotting risk is so severe. Even for these people, however, supplements and diet changes are likely to make the anticoagulation effects safer and to reduce some of the side effects of warfarin.

Here I’m going to outline some of the best measures outside of medications that you should discuss with your doctor about how to reduce the risk of side effects from warfarin and possibly, over time, get off of it entirely. I must caution you that although getting off of warfarin is a definite possibility for many people, this is not something you want to do quickly because your body needs time (maybe even over a year) to lower its innate clotting risks affected by some combination of the supplements below before you should risk discontinuing warfarin entirely.

Making Warfarin’s Vitamin K Interaction More Consistent

Warfarin works by interfering with the biological activity of vitamin K. Although vitamin K is fat soluble and therefore should in theory persist longer in the body than many water soluble nutrients, the reality is that most people get too little vitamin K and they tend to eat a “bursty” diet of vitamin K foods. If you eat some tasty kale and a spinach salad one day and then only have a piece of iceberg lettuce on a burger for your greens the next, you are creating peaks and valleys in your circulatory vitamin K levels. What this means is that on the days you eat a lot of vitamin K, the warfarin won’t protect you against abnormal clotting as well. And on the days you eat much less, you are far more likely to see a rise in your INR (clotting time) measurement that means you are a higher risk for abnormal bleeding.

Abnormal bleeding can be just as lethal as abnormal clotting. If there was a way to maintain more consistent levels of vitamin K then warfarin would probably be a safer drug. One step would be to carefully calculate how much vitamin K you get in the foods you eats and to modify or time your diet to keep daily vitamin K intake steady. Unfortunately, this is really not so easy to do as you may not always know what is in the foods you are eating and with people’s busy schedules, a shift of a planned meal by a few hours could still leave you with peaks and valleys in vitamin K.

Fortunately there are practices using supplements that can help stabilize vitamin K. The first one is to get a supply of supplements containing vitamin K2 of both the forms MK4 and MK7 and to take them at a consistent time each day every day with a meal containing fats and apart from any fat-blockers such as fiber and Orlistat that would impede the vitamin K absorption.

MK7 lasts in the body about 24 to 72 hours. Vitamin K1 lasts around 8 hours. MK4 lasts even less time, often stated as “a few hours”, but is more rapidly absorbed by the body than the K1 form commonly found in foods and supplements.

Vitamin K2 MK7 supplementation at levels around 50 to 150 mcg (micrograms) per day is likely to create a much more stable level of vitamin K in your bloodstream while still allowing warfarin to reduce clotting activity. So when you eat that kale or spinach salad, instead of your vitamin K levels skyrocketing by hundreds of percent perhaps they will go up only 50%. The reverse applies, too, that on days when you don’t eat much vitamin K in your diet you will not see as big of a drop in your blood reserves. Overall, this means that the warfarin dosage you can take probably will need to be a little higher but it will often be more stable and less important to get frequent tests to track the changes.

You might time your vitamin K2 MK4 intake to correspond with a meal containing some fat that also contain the least natural vitamin K of your daily meals. Typical breakfast foods (cereals, milk, toast, eggs, etc.) often don’t have much vitamin K but do have some fat, so taking your vitamin K2 MK4 with this meal might be a good choice. It may be appropriate to take part of your warfarin dosage at the same time as a vitamin K supplement containing K1 or K2 MK4 forms in order to ensure the uptake of the extra vitamin K doesn’t cause an excessively large drop in anticoagulation effect.

You may have to argue with your doctor over the entire concept of vitamin K supplementation for warfarin patients. Many of them are under the mistaken belief that vitamin K supplements are dangerous for warfarin patients. That’s not quite right. What is probably most dangerous is that consuming widely inconsistent amounts of vitamin K which is precisely what is happening due to the varying diet of many or even most people taking warfarin.

If your doctor is not receptive to these ideas, you may want to look for an integrative health care practitioner who is familiar with combining medications and supplements to get a better effect than you are likely to obtain from medicines alone.

Calcium Control

Probably the worst long-term problem with warfarin is that by interfering with vitamin K biological activity, it causes calcium to leach out of your bones (raising your risk for osteoporosis) and into your blood. The calcium may attach at a higher than normal rate to the inside of your blood vessels, heart valves, and possibly other non-bone tissues with large enough blood flow volume to keep the calcium coming to the area. In short, this causes vastly increased rates of calcification which can damage heart values, organs with high circulatory volumes such as the liver and kidney, and most obviously all of your blood vessels. Calcification makes them more rigid and creates higher risk for high blood pressure. It’s not far off to say that warfarin causes people to “grow bones in their blood vessels”!

It’s important to keep a watch on your calcium levels in your blood if you are taking warfarin. The body is fairly good at keeping stable levels, but if you see the levels rising or falling much from previous tests it can be a warning sign that something is going wrong with your vitamin K and warfarin interaction.

The danger of aggravated calcification during long-term use of warfarin is so significant that patients should talk with their doctors about getting a CT heart scan with calcium scoring to establish a baseline measurement of calcification and then rechecking to see how the drug over a period of a year or more may be rapidly and measurably worsening the calcification.

It may be also worthwhile to get a bone density measurement, such as a DEXA scan, to monitor for how warfarin may be aggravating bone loss to the degree it triggers osteoporosis. As warfarin is often prescribed in senior citizens who are already at elevated risk for osteoporosis and life-threatening falls and fractures, it is especially important to monitor and reduce the loss of bone integrity caused by this drug.
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Widely Used Anticoagulation Drug Warfarin (Coumadin) More Dangerous Than Commonly Thought

Warfarin is an anticoagulation medicine that is one of the most widely prescribed medicines in the world. It is sold under a variety of brand names, the best known of them being Coumadin in the US. Warfarin is used widely for people with blood clotting disorders. Millions of people are prescribed warfarin as their doctors claim it will help to keep them free from blood clots. Often they are placed on this medication after a DVT (deep vein thrombosis) in a leg or pulmonary clots in their lungs. Warfarin probably is a reasonable short-term quick-fix for abnormal blood clots, but long-term warfarin usage has some significant risks.

Long-term warfarin usage is tied to increased arterial calcification, osteoporosis, and cardiovascular disease. Perversely, it clogs up the circulatory system and could actually increase the risk of dangerous clots over time. A more comprehensive anticoagulation program that reduces or eliminates the use of warfarin by adjusting diet and adding certain supplements might achieve a better long-term outcome with reduced risk of both blood clots and abnormal bleeding plus reduced risk of the related cardiovascular and bone health problems that warfarin can exacerbate.

A few years ago, Dr. William Davis, a well known cardiologist and author of the best-selling book Wheat Belly: Lose the Wheat, Lose the Weight, and Find Your Path Back To Health, cited a simple example of how warfarin can severely raise the risk of heart attack by causing greatly accelerated cardiovascular calcification:

Quoted from Warfarin is scary stuff:

Gilbert is a 58-year old high school science teacher.

When I first met Gil, he’d been having bouts of atrial fibrillation and had required various medications to suppress recurrences of the rhythm. However, because his rhythm proved somewhat difficult to control, his electrophysiologist (heart rhythm specialist) prescribed warfarin to reduce the risk of stroke. With atrial fibrillation, because of blood stagnation (in the left atrial appendage) in the heart, there is a stroke risk of approximately 8% per year. Warfarin reduces this risk substantially, to about 2%.

I met Gil because he had a cholesterol disorder. In my practice, the first step in gauging the implications of a lipid or lipoprotein disorder is to obtain a heart scan. If the heart scan score is zero, great. It means that we have plenty of time to treat the disorder since risk for cardiovascular events is near zero also; it means less intensive efforts are necessary. But if the heart scan score is, say, 1200, then an aggressive approach in short order is required, since the risk for heart attack may as high as 20-25% per year, even in the absence of symptoms.

Gil’s heart scan score: 787–high and posing a risk for heart attack of about 5-10% per year without preventive efforts. Gil did indeed prove to have a complex lipoprotein disorder, as well as high blood pressure, vitamin D deficiency, and several other potential contributors to coronary plaque.

Gil did just about everything right: He exercised, followed the recommended diet, achieved better than the Track Your Plaque 60-60-60, lost 18 lbs of abdominal fat.

Gil’s rhythm stabilized for several months, only to have atrial fibrillation break through again. So Gil’s electrophysiologist re-prescribed warfarin.

18 months later, Gil’s 2nd heart scan score: 1410–a near doubling.

Davis believes it is the warfarin that greatly aggravated the heart scan calcium score. Warfarin displaces calcium from the bones and that calcium ends up somewhere, most often on the inside of blood vessels and the heart where it greatly raises the risks of cardiovascular disease and consequent early death. And this is one of the major reasons why anybody prescribed warfarin should be looking hard for alternatives that would help reduce dangerous side effects and allow lowering the dosage of warfarin or discontinuing it entirely. In Gil’s case, the drug Pradaxa (generic Dabigatran) might be an option as it has been approved in some locations for use in reducing clotting risk related to atrial fibrillation. However, as with most drugs, it has risks of its own.

Clotting Is Normal and Safe Until It Gets Out of Control

In medical writings discussing clotting disorders, you’ll often see mention of “thrombosis”. Any time you see “thrombosis” simply think of it as doctor-speak for a clot that has occurred inside a blood vessel.

Clotting is a normal process of the body. It’s important to stop blood loss so that damaged tissues can be repaired. The body normally produces many tiny clots to stop bleeding not only in cuts and bruises but even within blood vessels and internal organs. This normally create no problems as they are so small that are reabsorbed over time or they pass through blood vessels and organs without causing any damage.

The danger from clots largely comes from when they grow large enough to block healthy blood flow and particularly if they break loose in big chunks and then travel throughout the body and lodge somewhere else blocking blood flow. This is more likely to happen in microscopic blood vessels, but the danger from a clot is much worse when it blocks a larger blood vessel. When this happens, parts of the body that are deprived of ample blood flow are often damaged severely. Most people are aware that blood carries oxygen and nutrients that cells need to survive. But blood is also a means to eliminate buildups of metabolic products that can harm cells. The bloodstream takes such substances to the kidney and liver where they can be processed into waste products or transformed into useful or at least less harmful substances.

Doctors and biomedical researchers often discuss ischemia and reperfusion injuries to tissues deprived of blood flow. Ischemia refers to an abnormal slowing or cessation of blood supply to tissues. Reperfusion refers to the blood flow being restored after a period of ischemia. Both can produce significant damage to tissues and both are major reasons for why clots are so dangerous. While it may seem counterintuitive that restoring blood flow could cause further damage, this happens because the restored blood flow often brings with it a barrage of inflammatory cytokines, free radicals, and oxidized biochemicals that further damage tissue already weakened by the ischemia.

Why Doctors Prescribe Warfarin and Anticoagulants

The best way to prevent ischemia and reperfusion damage is to prevent any interruption of blood flow in the first place. Once a patient has experienced an abnormal blood clot, doctors generally regard this patient as at high risk for further clots unless they can explain away the clot as being caused by some unusual event such as an injury or surgery. If they can’t find a good explanation like that, doctors will generally run a series of tests looking for genetic and immune markers that are commonly found in people with high clotting risk. If they find some of these risk factors, they are likely to prescribe warfarin or other anticoagulants on a long-term basis for years or more. Often they will tell such patients they must continue to use these drugs “for life”.

How Warfarin Prevents Clots

Many people call warfarin a “blood thinner” but that’s a misnomer. It doesn’t actually change the viscosity of blood. Instead, it works by interfering with vitamin K metabolism in the liver involved in producing various clotting proteins, particularly prothrombin (factor II) and factor VII. By decreasing the available amount of these proteins, the body’s ability to create blood clots is reduced. But prothrombin and factor VII are just two of the many clotting proteins involved in a clot.
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Melatonin Helps Improve Sleep and Boost Immune System, Little Sign of Toxicity Even At Very High Doses

Melatonin is a hormone produced by the pineal gland from the body’s supply of serotonin. Its best known use is to help regular the daily sleep/wake cycle. It also functions as a strong antioxidant and an immune system booster. It’s even been studied and advocated for use in preventing damage to humans from ionizing radiation. For such reasons, many in the anti-aging community advocate taking supplemental melatonin before each night’s sleep to improve overall health and sleep quality.

In healthy people, the dark hours of the day when you should be sleeping result in increased release of melatonin. It helps you fall asleep and stay asleep until the morning. Exposure to light, particularly bright lights, diminishes the body’s production of melatonin and at least partly explains why many people do not sleep well during the day even if they are very tired.

To have good melatonin levels and healthy sleep, you should keep your room dark. Even soft lighting can significantly lower the body’s melatonin production:
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Amla and Pycnogenol May Powerfully Lower Dangerous C Reactive Protein and Fibrinogen Levels

Recently I reviewed some blood test results going back a few years for a person who has a blood clotting disorder. Because of a past history of multiple abnormal blood clots throughout the body even while taking the dangerous anticoagulant drug warfarin prescribed by multiple doctors he’s seen, he began to doubt the doctors’ knowledge as their treatments were not working well. A comprehensive supplementation program including among other things omega 3 fish oils, anti-inflammatories such as curcumin, and proteolytics such as nattokinase, bromelain, and serrapeptase have enabled him to discontinue warfarin and avoid the clots that the warfarin treatment was not successfully stopping.

Based upon the results I examined, it appears the amla (Indian gooseberry, embilica officinalis) and Pycnogenol (brand name of pine bark extract) that he recently added to his array of supplements may be having a powerful beneficial effect on the cardiovascular and clotting risk factors measured by the C Reactive Protein (CRP) and fibrinogen blood tests. The effects appear so strong in a short period of time that I think these supplements should be tried by many people who are at risk for cardiovascular disease or abnormal blood clots. After a period of one to two months, their test results could be easily examined to see if Amla and Pycnogenol are working well as it appears they are for this man.

He was motivated to find something to lower his C Reactive Protein test results after a disturbingly high CRP test result of 6.47 mg/L. Additionally, he had been experiencing chronic pain throughout his body and read that some people with chronic pain such as osteoarthritis experience elevated CRP levels as underlying inflammatory conditions are driving their pain. This CRP result was almost double that of an already poor result of 3.73 about a year earlier when his pain levels were much less, so he suspected it might be connected. In less than a month of usage of a Life Extension product containing AmlaMax, a standardized Amla extract, he saw his CRP test result drop to 1.67 and noted some improvement in pain levels, too. As guidance, Life Extension’s optimal recommendations for CRP for men is less than 0.55 mg/L and the LabCorp reference range for men is less than 3 mg/L.
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Abnormal Cortisol Levels, Depression, Anxiety, and PTSD Are Signs of Long-Term Abuse and Psychological Trauma

Long-term emotional stress is a well-known culprit in the development of abnormal cortisol levels and consequent damage to the endocrine system of hormone-releasing organs throughout the body, most notably the adrenal glands that produce cortisol itself. Most of the research on this common health problem has been conducted in adults, but it turns out that abused children experience many of the same health effects seen in stressed out adults. Furthermore, studies are showing that chronic abuse can disrupt the balance of the HPA (hypothalamus-pituitary-adrenal) axis for many years or decades.

Child Abuse Triggers Abnormal Cortisol Levels

Researcher Kate Harkness looked at the relationship between cortisol levels and abuse and mental illness in children and found a strong connection. She believes that the high stress levels experienced in many children who are being physically, emotionally, or sexually abused drive up cortisol dramatically. Over time, the high levels of cortisol damage the brain in regions such as the hippocampus and hypothalamus. Chronically elevated cortisol also damages the endocrine system consisting of hormone releasing organs such as the adrenal and pituitary glands. Abnormal levels of cortisol have also been linked as a factor contributing to the development of many other health problems involving metabolic disorders such as diabetes, high levels of blood lipids, and low CoQ10 levels.
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Stevia Is Healthier Alternative To Artificial Sweeteners That Trigger High Blood Glucose

“Sugar is the enemy!” is the mantra of many in the weight loss industry. Partly as a result of this, the use of artificial sweeteners has skyrocketed in the past several decades. Aspartame was approved for use in foods by the US FDA in 1974. (NutraSweet is probably the most common brand of aspartame, AminoSweet is another.) Since then it has been widely used in many foods and drinks to reduce their calorie content while maintaining a sweet taste. This should in theory reduce the calories consumed. But despite the wide use of zero calorie artificial sweeteners, the epidemics of diabetes, metabolic syndrome, and obesity have worsened severely. Could it be that artificial sweeteners have unintended consequences that may lead to unhealthy weight and metabolic problems?

Many of the most avid consumers of diet soft drinks and foods are severely overweight. This caused researchers to wonder how can that be if they cut their calorie intake by replacing sucrose (the table sugar mix of 50% glucose and 50% fructose) with zero-calorie artificial sweeteners? Several studies show it does reduce calorie intake if the volume of food consumed stays the same. But others suggest that people consuming artificial sweeteners may eat more calories via increased overall volume of food intake.

Aspartame May Raise Blood Glucose Levels

Surprisingly, it appears that artificial sweeteners such as aspartame may actually raise blood glucose levels much like regular dietary sugars (sucrose and fructose) do even though they do have fewer calories. There are some indications that they also increase appetite. They may do so by mechanisms similar to how consuming sugar raises blood glucose and often produces an insulin surge that later results in increased appetite as high insulin lowers blood glucose excessively and triggers hunger to push a person to eat more to once again raise the blood glucose levels.

Because of their impact on glucose and insulin, artificial sweeteners could lead to health problems such as metabolic syndrome, diabetes, and abnormal blood lipids much like regular sugars. But the risks from one of the most common artificial sweetners, aspartame, may be worse than that.
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Swanson Vitamins Coupon Codes for 10% Discount and $1.99 Shipping for July 2011

Use the coupon code EXPO511 (case-sensitive) at Swanson Health Products for 10% off your order. This code was working on July 11, 2011. The expiration date is unknown.

Use the coupon code SWAN199 (case-sensitive) at Swanson Health Products for $1.99 standard shipping on your order. This code was working on July 11, 2011. The expiration date is unknown.

The company only allows you to use one promotional or coupon code at a time. Enter your selected code during checkout or via the Have A Promo Code? link to start using your discount code during the shopping process. Note that shipping discounts do not appear until checkout.

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