Glucosinolates and Sulforaphane in Broccoli and Cruciferous Vegetables May Help Prevent and Treat Cardiovascular Disease, Diabetes, Bacterial Infections, and Some Cancers

broccoli

Sulforaphane is a biochemical nutrient found naturally in broccoli and many other cruciferous vegetables. It is created by a reaction between the enzyme myrosinase and glucoraphanin, one of the forms of glucosinolates found in cruciferous vegetables that is readily converted to sulforaphane.

Researchers have found that sulforaphane has some very wide-ranging healthful properties. Anybody seeking to maximize their health should consume a considerable amount of sulforaphane in their diet from foods or supplements. Cruciferous vegetables such as broccoli are among the best sources of sulforaphane. Sprouts are better sources than mature plants. Differences in food preparation have a vast impact on the amounts of sulforaphane available from foods.

Sulforaphane Fights Atherosclerosis and Cardiovascular Diseases

Inflammation in the lining of blood vessels is believed to be an early factor in the development of atherosclerosis. The clogging of the arteries and veins of the human circulatory system due to atherosclerosis is a contributing factor in strokes, heart attacks, DVT (deep vein thrombosis) blood clots, and many other cardiovascular health conditions. New research shows that some of the most susceptible areas of the arteries are those with bends or branching shapes. It appears this is due to how they lack the active version of a protective protein known as Nrf2. That’s because the Nrf2 in these areas is often bound to other proteins that inactivate it. Sulforaphane, found naturally in broccoli and many other cruciferous vegetables, helps turn on the Nrf2 and thereby reduce the risk of inflammation and consequent injuries.

Sulforaphone also helps fight other inflammatory processes related cardiovascular diseases. It has been found to inhibit the activity of several inflammatory molecules found in the human body including NF-kB (Nuclear Factor kappa B), prostaglandin E2, and nitric oxide. It appears to help induce enzyme detoxification of upper respiratory pathway contaminants such as pollutants and pollens. And it helps block the production of TNF-a (Tumor Necrosis Factor alpha) in some immune cells that contributes to inflammatory conditions such as rheumatoid arthritis.

Sulforaphane Helps Reduce Diabetic Health Damage

There is some evidence that sulforaphane can help prevent damages from high glucose levels found in diabetics. It appears to do so both by the Nrf2 protein activation mentioned above and also by greatly reducing ROS (reactive oxygen species) levels by boosting the production of the endogeneous antioxidant glutathione peroxidase and the enzyme transkelotase. More research is being done on its applicability in diabetes treatment.

Sulforaphane Exhibits Broad Spectrum Antibacterial Activity

Researchers have found that sulforaphane acts to impeded the growth of many harmful bacteria including Escherichia Coli and Salmonella, common sources of food poisoning and urinary tract infections in humans. Another bacterial target susceptible to sulforaphane is Helicobacter pylori which is responsible for many ulcers and also a suspected cause of gastrointestinal cancers. A 2009 Japanese study of broccoli’s effect on Helicobacter pylori found that consumption of about 70 grams (2.5 ounces) of broccoli sprouts daily for two months reduced Helicobacter pylori colonization in the stomach by about 40%. Infection returned to previous levels two months after discontinuation of the broccoli sprouts, so continuous use is probably necessary for anybody who is struggling with ulcers and related medical problems caused by the bacteria.

Other infectious bacteria strains impeded by sulforaphane include shigella (responsible for dysentery), staphylococcus aureus (implicated in many kind of infections ranging from minor skin infections to deadly pneumonia), streptococcus pyogenes, pseudomonas aeroginosa, and cryptococcus neoformans.


Sulforaphane Acts As A Cancer Chemopreventative

Sulforaphane is also being researched for use in cancer prevention and treatment. A study titled Sulforaphane, a dietary component of broccoli/broccoli sprouts, inhibits breast cancer stem cells in 2010 showed that sulforaphane treatment reduced breast tumor growth in live mice. Other studies discuss how sulporaphane inhibits breast cancer stem cells and inhibits oral carcinoma cell migration.

The study Phytochemicals Resveratrol and Sulforaphane as Potential Agents for Enhancing the Anti-Tumor Activities of Conventional Cancer Therapies suggests combining sulforaphane with anti-cancer drugs to potentiate them at lower dosages and reduce the risk of side effects.

Isothiocyanates I3C (indole 3 carbinol) and DIM (diindolylmethane) are other common biochemicals found in broccoli that are also responsible for reputed cancer preventative effects. A recent paper entitled Selective Depletion of Mutant p53 by Cancer Chemopreventive Isothiocyanates and Their Structure−Activity Relationships discusses one of the cancer preventative mechanisms they offer involves their interaction with the p53 tumor suppressor gene to help keep healthy cells from becoming cancerous. The study, run by Fung-Lung Chung and colleagues at Georgetown University and Columbia University, examined the effects of several types of isothiocyanates on cancer cells from colon, breast, and lung cancer tumors.

There is some concern that extraordinarily high dosages of certain isothiocyanates other than sulforaphane, for example benzyl isothiocyanate and phenethyl isothiocyanate, could increase the risk for bladder cancer in the presence of certain chemical carcinogens. However, most studies have found that sulforaphane is beneficial at typical dosages for chemoprotective effects against chemical carcinogens. This may suggest that taking supplements containing significant quantities of preformed sulforaphane may be preferable over eating extraordinarily large quantities of cruciferous vegetables.

Good Food Sources of Sulforaphane

The best food source of sulforaphane is generally broccoli sprouts, but it is also found in mature broccoli and other cruciferous vegetables in substantial quantities. Many sources say sprouts offer about 10 to 100 times the concentration of sulforaphane versus mature plants. Mature plants have much higher concentrations of indoles, another class of compounds with reputed effects on cancer prevention and hormone balancing.

A recent study points to how combining broccoli sprouts and broccoli powder almost doubles the amount of sulforaphane absorbed by the body. This may be due to how mature plants have more sulforaphane precursors such as glucoraphanin that can be converted to sulforaphane in a healthy digestive tract. Given the difference in indoles, also, it likely makes sense to consume both sprouts and mature plants to get the benefits of both.

Some of the best sources of sulforaphane include:

  • Broccoli sprouts
  • Cauliflower sprouts
  • Broccoli
  • Cauliflower
  • Brussel sprouts
  • Cabbage
  • Collard greens
  • Kale
  • Mustard greens
  • Radishes
  • Rutabaga
  • Arugula
  • Turnip
  • Wasabi (a Japanese food)
  • Watercress

Not all supplements and foods are equally good at getting sulforaphane into the body. The enzymes myrosinase reacts with glucoraphanin (also known as sulforaphane glucosinolate), one of the glucosinolates found in cruciferous vegetables, transforming it into sulforaphane. This happens when the microscopic sacs containing these compounds are broken open, allowing them to react. Physical damage such as chewing and cutting and light steaming tend to break open the sacs and allow the reaction to proceed to generate sulforaphane without destroying most of the myrosinase before it can react. Human intestinal microflora may be able to convert some of the glucoraphanin into sulforaphane, also, but people who have digestive health problems are likely to be unable to convert much of it unless there is myrosinase enzyme available in the foods or supplements to assist. Many broccoli products lack significant amounts of myrosinase, so when choosing supplements it may be best to pick products that include some standardized amount of sulforaphane versus those that simply list glucosinolates among their components without specifying sulforaphane.

Preparing Broccoli to Maximize Sulforaphane Availability

The myrosinase enzyme is inactivated or destroyed via overcooking for long durations or at high temperatures, leading to little available sulforaphane from such foods. As much as 90% of the potentially available sulforaphane may be eliminated from foods by overcooking. Unfortunately, that means a yummy broccoli soup you like so much is probably a poor source of sulforaphane.

This might lead you to consider eating your broccoli raw. However, sulforaphane in raw broccoli can be poorly available because the myrosinase and glucoraphanin are bound up and unable to react to create sulforaphane. Cutting, chopping, and crushing raw broccoli frees the myrosinase and glucoraphanin allowing sulforaphane to be generated. Probably the best possible way to prepare cruciferous vegetables for maximum sulforaphane benefit is to finely chop or grate them raw and then eat them shortly thereafter.

Lightly steaming broccoli also helps to free up the myrosinase and glucoraphanin to create bioavailable sulforaphane, but it is easy to overcook and deplete the food of useful sulforaphane. Microwave cooking is thought to be less effective at making the sulforaphane bioavailable than steamer cooking.

When you cook cruciferous vegetables, many of the glucosinolates dissolve into the cooking water. This is part of why steaming is advantageous because there is little water involved. You could choose to drink the cooking water as it will have many glucosinolates in it.

Broccoli is by far the best researched source of sulforaphane. Similar guidelines likely apply to preparing other cruciferous vegatables to maximize their beneficial sulforaphane, but further research is needed to substantiate this conclusively.

A recent Chinese study on bioavailability of sulforaphane from two broccoli sprout beverages shows that beverages with high levels of glucoraphanin tend to produce lower elevations in sulforaphane that last longer whereas those with high levels of sulforaphane attain higher concentrations but they wash out more quickly. The authors conclude that it is probably more effective to mix glucoraphanin and sulforaphane in foods and supplements to achieve best effect by reaching both high peak concentrations of sulforaphane in the body and sustaining lower levels for longer periods of time.





Sulforaphane Dosages

Some suggest total daily dosages of sulforaphane should be around 50mg to 100mg for optimal effect. It is my belief that such suggestions are referring to sulforaphane glucosinolate which can be converted to sulforaphane in the body, not to sulforaphane directly. Many supplements include only 400 micrograms to 2 milligrams of sulforaphane itself. Others include various glucosinolates but their ingredient lists make no mention of preformed sulforaphane. It is important to realize that the body’s ability to convert glucosinolates to sulforaphane depends upon adequate myrosinase and/or healthy gut bacteria populations.

Please be clear that you have to pay very close attention to terminology to be sure of your understanding of a research paper or supplement label as some refer to sulforaphane and others refers to sulforaphane glucosinolate which are not the same compounds. Often these materials use “SGS” as an abbrevation for sulforaphane glucosinolate. A product that claims that it offers 400 mcg (micrograms) of sulforaphane may actually be more potent than one which claims it offers 5 mg of SGS or sulforaphane glucosinolate, even though 5 mg is certainly a larger mass than 400 micrograms.

There are a couple of supplements available with larger dosages of sulforaphane precursors at 30mg per capsule from Jarrow Formulations and Xymogen (shown to the left). Both of these products list sulforaphane glucosinolate, not sulforaphane, as a component of their formulations. The Xymogen product also contains a number of other Nrf2 activators such as pterostilbene, a compound similar to resveratrol but with bioavailability claimed to be much higher.

As sulforaphane is rapidly absorbed and metabolized, it’s important to take multiple doses per day for sustained effect.

Foods have highly variable quantities of sulforaphane and its glucosinolate precursors. Most of them are rich in glucosinolates but have little preformed sulforaphane. In a healthy digestive tract, bacteria will convert many of the glucosinolates to sulforaphane, especially if there is plenty of myrosinase enzyme in the food because it is raw and has been broken up into very small pieces. If you have digestive problems related to use of antiobiotics wiping out your digestive tract bacteria, it’s likely that little conversion to sulforaphane will take place. You may want to investigate using probiotrics and prebiotics to rebuild the healthy digestive tract flora and select glucosinolate and sulforaphane supplements that contain significant quantities of preformed sulforaphane.

Some studies show that a 100 gram (3 ounce) serving of broccoli sprouts offers about 250 mg of sulforaphane glucosinolate (glucoraphanin). If you can obtain fresh broccoli sprouts that are clean and in fresh and crunchy condition, this might be one of the best sources of the nutrient as it is easy to put them on salads and sandwiches. Raw salads including mature chopped broccoli, cauliflower, and cabbage are another good source, but you have to consume far more of them to get the same amount of sulforaphane.

Here are some estimated quantities of glucosinolates in various raw vegetables:

Brussel sprouts – 1/2 cup (44g) has about 104mg
Garden cress – 1/2 cup (25g) has about 98mg
Mustard greens – 1/2 cup chopped (28g) has about 79mg
Turnip – 1/2 cup chopped into cubes (65g) has about 60mg
Savoy cabbage – 1/2 cup chopped (45g) has about 35mg
Kale – 1 cup chopped (67g) has about 67mg
Watercress – 1 cup chopped (34g) has about 32mg
Kohlrabi – 1/2 cup chopped (67g) has about 31 mg
Red cabbage – 1/2 cup chopped (45g) has about 29mg
Broccoli (mature) – 1/2 cup chopped (44g) has about 27mg
Horseradish – 1 tablespoon (15g) has about 24mg
Cauliflower (mature) – 1/2 cup chipped (50g) has about 22mg
Bok choy or Bok choi – 1/2 cup chopped (35g) has about 19mg


Cruciferous Vegetable Soups - Life Extension

Further Reading

New research shows how broccoli beats cancer

The Coming Age of Vege-Medicine

Kale: Powerful Cancer Protection and Healthy Eye and Heart Benefits

I3C & DIM: Natural, Dual-Action Protection Against Deadly Cancers

Basis for Broccoli’s Cancer-Fighting Ability Revealed

Broccoli: Providing Cancer Protection, Liver Support, and Essential Nutrients

Researchers at University of Illinois Release New Data on Diet and Nutrition

Sulforaphane Glucosinolate Monograph

Research reveals a broccoli boost for arteries

Broccoli and Diabetes

Dietary Sulforaphane-Rich Broccoli Sprouts Reduce Colonization and Attenuate Gastritis in Helicobacter pylori–Infected Mice and Humans

Phytochemicals Resveratrol and Sulforaphane as Potential Agents for Enhancing the Anti-Tumor Activities of Conventional Cancer Therapies

Sulforaphane, a dietary component of broccoli/broccoli sprouts, inhibits breast cancer stem cells

Sulforaphane Inhibits Oral Carcinoma Cell Migration and Invasion In Vitro

Concurrent Sulforaphane and Eugenol Induces Differential Effects on Human Cervical Cancer Cells

Synergistic activity of Sulforaphane (Broccozym) and Parthenolide (Butterzym) abolishes cancer stem cell characteristics

A major inducer of anticarcinogenic protective enzymes from broccoli: Isolation and elucidation of structure

Fruit and vegetable intake and incidence of bladder cancer in a male prospective cohort

Selective Depletion of Mutant p53 by Cancer Chemopreventive Isothiocyanates and Their Structure−Activity Relationships

Bioavailability of Sulforaphane from two broccoli sprout beverages: results of a short-term, cross-over clinical trial in Qidong, China

Broccoli sprouts: an exceptionally rich source of inducers of enzymes that protect against chemical carcinogens

Sulforaphane absorption and excretion following ingestion of a semi-purified broccoli powder rich in glucoraphanin and broccoli sprouts in healthy men

Cooking Broccoli Destroys 90+ Percent of Anti-Cancer Compound Sulforaphane

Discovery may help scientists boost broccoli’s cancer-fighting power

Linus Pauling Institute: Isothiocyanates

Linus Pauling Institute: Indole 3 Carbinol

Xymogen Nrf2 Activator with 30mg of sulforaphane

Jarrow Formulas BroccoMax with 30mg of sulforaphane

How should I eat my kale, raw or cooked?


These statements have not been evaluated by the Food and Drug Administration. The products mentioned in this post and on this website are not intended to diagnose, treat, cure or prevent any disease. The information presented here is for educational purposes and does not constitute medical advice. Please obtain medical advice from qualified healthcare providers.


Comments

Glucosinolates and Sulforaphane in Broccoli and Cruciferous Vegetables May Help Prevent and Treat Cardiovascular Disease, Diabetes, Bacterial Infections, and Some Cancers — 9 Comments

  1. My husband, a very healthy 40 something, recently got lung blood clots on two separate occasions. Neither he, nor anyone in his family, has any prior history of blood problems. Tests ruled out HIT, Lupus etc, leaving the doctors without an answer.

    Both times, he began with an H. Pylori infection, in late 2009 he was treated with Amoxycillen, and the subsequent lung problem was treated with a variety of drugs including Albuteral. Six weeks later he had a severe pulmonary embolism and a clot in the vena cava.

    The second time he got the lung clot in May 2011; he was given Sulfametazsol and Acetomenaphine for the initial stomach ailment, and was already taking a Heparin based drug due to the previous blood clot. We know he developed a blood clot within a month of the stomach problems, because Cat scans were completely clear of clotting a month earlier.

    The doctors want to put him on lifelong Arixtra and/or coumadin for life.

    I’m terrified not only because of the side effects, but also because I know that these drugs, or interactions of drugs, caused the clots in the first place. HELP!

    • Michelle,

      By “lupus” I assume you mean “lupus anticoagulant”? That is a poorly named condition in which the body makes antibodies against anti-clotting proteins. It is a condition that can come and go, sometimes it is driven by a immune system reaction to some environmental factor such as an infection or toxin.

      Was he tested for other coagulation disorders such as Factor V Leiden, Protein S, and Protein C?

      Factor V Leiden is a very common genetic disorder especially in people with European ancestry, possibly around 5% of the US and Canadian Caucasian population has it. Many have it heterozygously, causing have of their Factor V clotting proteins to be made in a fashion that they cannot be inactivated. But it is much more dangerous to have it homozygously, causing all the Factor V to have this defect.

      Protein S and Protein C deficiencies can lead to increased risk of clots (thrombosis) and pulmonary embolism, but they are probably less common than Factor V Leiden.

      It’s possible to have combinations of these conditions, they are not mutually exclusive.

      What other blood test data does he have? Has he had his homocysteine, fibrinogen, blood lipids (cholesterol and triglycerides, preferably via VAP or NMR LipoProfile tests rather than the usual cheap but seriously incomplete blood profile tests most doctors use), CoQ10, CRP, inflammatory cytokines, thyroid hormones, adrenal and sex hormones (particularly DHEA, testosterone, and estrogen), and vitamin B12 and folate levels tested? All of these may show risk factors for elevated clotting potential.

      Arixtra is similar to the heparins, a class of injection anticoagulants.

      Coumadmin (warfarin) is a vitamin K antagonist that prevents formation of coagulation proteins. It is highly sensitive to vitamin K in the diet and is difficult to manage unless patients are tested often to monitor for effect on clotting and diets are kept with very consistent levels of vitamin K. In practice, this often is difficult to do for people who enjoy salads and many plant foods. Green vegetables in particular often have considerable vitamin K. If you are using warfarin and vary your diet from day to day, some days have a big salad or lots of green vegetables and other days eat none, it is likely this drug will result in insufficient anticoagulation effect at some times and excessive effect and tendency to bleed too easily at others.

      Warfarin is widely used, but I really can’t recommend using warfarin on a long term basis. There are many problems with it. For one, the diet sensitivity problems are a major cause of clots and abnormal bleeding. Even if you could keep the diet totally consistent, however, warfarin is still dangerous because it tends to remove calcium from the bones and deposit in in the circulatory system, leading to osteoporosis and atherosclerosis with calcification effects that are likely to increase the risk of clotting and embolisms on their own.

      I’d recommend that you further investigate the usage of high dosage fish oil, niacin, carnitine, policosanol, garlic extract, folate, vitamin B12 (particular methylcobalamin form), TMG (trimethylglycine) or choline, proteolytics (bromelain, nattokinase, serrapeptase), anti-inflammatories (curcumin and tumeric, nettle leaf and root, etc.), low-dosage aspirin (81mg per day) and other anti-platelets such as grape seed extract and nexrutine, and lots of antioxidants such as vitamin C, NAC (N-acetyl-cysteine), lycopene, mixed tocopherol and tocotrienols (vitamin E variants), green tea extract, and CoQ10 and maybe idebenone (a synthetic CoQ10 variant). Possibly DHEA and testosterone and/or estrogen altering supplements or medications could be useful, too, as unbalanced levels of adrenal and sex hormones can increase risk of clotting.

      The proteolytics such as bromelain, nattokinase, and serrapeptase can help break down excess clotting proteins such as fibrinogen, thus preventing abnormal clots from forming or enlarging.

      Inflammation often leads to clots. Helping to reduce overall inflammation may therefore help lower the risk of clots. That’s where supplements like curcumin (tumeric), nexrutine, nettle leaf and root, boswellia, and some others may help.

      Abnormal lipid profiles, for instance very high levels of cholesterol, may clog up the circulatory system and make it more likely to suffer from tiny clots that are not dangerous on their own getting stuck and growing into much larger clots that are very dangerous. Fish oil can help get the lipids under control. Carnitine supplements often help dramatically lower abnormal blood lipids by allowing the mitochondria to burn off lipids as energy sources much more effectively. Niacin, policosanol, and tocotrienols are also noted for helping to lower cholesterol and triglyceride levels. There are some proprietary tocotrienol formulations with additional ingredients such as Sytrinol (which adds citrus extracts) that may also help in this area. Antioxidants (vitamin C, NAC, vitamin E tocopherols and tocotrienols, lycopene, etc.) help lower the rate of lipid oxidation that also affects clotting risk.

      Pomegranate extract and GliSODin can help reduce thickening of arteries and risk for atherosclerosis. Wider openings in blood vessels reduce the chance for tiny clots getting stuck and creating big problems.

      Homocysteine is a major risk factor for cardiovascular disease and atherosclerosis. Folate or folic acid, vitamin B12 (especially methylcobalamin), and methyl donors such as TMG (trimethylglycine) and choline can all help significantly lower homocysteine levels.

      I’ll try to get back to writing something more about this at a future time. The topic is quite complicated, there are many interacting factors. I believe this is one of the reasons that warfarin therapy often works poorly for long-term usage. It only addresses one factor with any significance and then piles on significant additional risk by interfering with the appropriate usage of calcium in the body.

      There’s a good article Blood Clot Prevention: Battling a Dangerous Condition by Life Extension that covers many of the factors involved with abnormal clotting and how to reduce the risk with dietary supplements. I’d strongly advise you start there to get an overall understanding of many of the common factors involved. It’s a comprehensive treatment, but not exhaustive as there is much additional information that even that excellent article does not include.

      Since it sounds like the H. pylori infections are a triggering factor in the clots, I’d recommend that your husband consider daily use of supplements that help reduce the growth of H. pylori. Take a look at Natural Solutions to Chronic Stomach Problems for some guidance on this. Zinc, zinc-carnosine, broccoli extracts (particularly sulforaphane and glucosinolates), cranberry extracts, licorice extracts, and others may be of help. Life Extension’s Carnosoothe with PicroProtect product combines these in one product, it or some similar combination of ingredients might be worth trying for a year or so to see if it helps put a stop to the recurring H. pylori infections.

      When using licorice extracts, consider that they can affect cortisol levels unless you use DGL versions in which the glycyrrhizin is removed. If it turns out your husband has high cortisol levels, he’d definitely want to avoid using any licorice products that have not had the glycyrrhizin removed. If he has low cortisol levels, it may be beneficial to use licorice products with the glycyrrhizin intact as they will help boost cortisol by interfering with the enzymes that break down the cortisol normally. Since you say he had good health, I’m guessing that his cortisol levels are probably normal, but chronic stress often causes imbalances in cortisol that create many health problems yet the cortisol imbalance often goes undetected. Chronic health problems often lead to chronic stress and vice versa, so you should both be aware of this.

      Also consider that many people as they get older have insufficient stomach acid and this can lead to digestive tract infections and also poor absorption of proteins. The use of betaine hydrochloride and pepsin and/or bromelain supplements can help increase stomach acid levels and protein digestive capacity.

      If there’s any way you can privately share your husband’s test results with us, preferably with all names and other identifying information redacted or otherwise removed, it would help me to understand the situation better and provide better suggestions for you.

      Often there are many factors contributing to clotting and doctors fail to address every one of them, leaving patients with an incomplete treatment. They do this in part because of cost pressures — warfarin is a really cheap drug. But ignorance is another major issue because many doctors put too much trust into pharmaceuticals without considering long-term consequences. Warfarin is a cheap and widely used quick-fix for DVTs and other hypercoagulable conditions, but I truly think it will badly damage most people’s health after it is used for multiple years.

      I hope this helps you some. If you can provide more information, I might be able to provide some more suggestions on things to investigate. Clotting conditions are very serious health risks, I’d strongly recommend that you find expert doctors in cardiovascular and pulmonary medicine and also find qualified alternative or integrative medical doctors to assist who can help provide the big-picture treatment that many specialists fail to address. It is very common for people relying entirely on warfarin for years to end up with additional clots or severe bleeding side effects. Given the nature of that drug, I’d consider it almost unavoidable for people who rely upon it exclusively without using several of the supplements I’ve mentioned to address other risk factors.

      Alison

      • Thanks so much for the wealth of information. I’m really not sure of all the specific tests done. I just know they tested him for numerous blood disorders.

        I will print out this information and study it thoroughly. I’m sure this will be helpful to others. Thanks so much!!!

  2. This is very exciting information. The first time I read something that overall makes sense. The doctors only answers are toxic medicines that didn’t help, much less cure the condition. I know deep down that all the medications made him sick. Now the doctors say he has to take them for life? No way.

  3. Pingback: Widely Used Anticoagulation Drug Warfarin (Coumadin) More Dangerous Than Commonly Thought | EmediaHealth

  4. Jarrow Broccomax has 2.8mg sulforaphane per 2 caps or 1.4mg/cap not the 30mg per cap as indicated in this article (it does contain 30mg of sulforaphaneglucosinolate). Vitacost has the greatest per serving, 3mg sulforaphane. Is this article indicating suggestive optimal dose of sulforaphane 50mg-100mg correct??? (Or is the author confusing sulforaphane with sulforaphaneglucosinolate) Or is it off by a factor of 10, 5-10mg per day???? Please e-mail a reply TY

    • cooch,

      Thanks for the comment. The ingredients listings are confusing because many products do not list any sulforaphane content. Others list it by sulforaphane or by sulforaphane glucosinolate (also known as glucoraphanin). Much discussion by others often does not differentiate between the two, but I believe that sulforaphane glucosinolate is converted into a much smaller quantity of sulforaphane. Some list glucosinolates, not stating how much of them may be the sulforaphane glucosinolate form that can be metabolized into sulforaphane. This variation in terminology is confusing even if you’ve spent some time reading about the benefits of sulforaphane and how glucosinolates are metabolized into sulforaphane.

      Where did you find the ingredients stating sulforaphane content in BroccoMax? Jarrow’s own web page on BroccoMax simply lists 30mg of sulforaphane glucosinolate, nothing is said about sulforaphane alone.

      I think the 50 mg to 100 mg per day cited by some probably is for sulphoraphane glucosinolates. Otherwise I do not see how one could realistically get those dosages without consuming an entire bottle each day of many broccoli extract supplements. But because of the way products are labelled, you can’t know with certainty how much sulforaphane you are likely to be able to get from any product. That’s especially so after considering variations in digestive and metabolic processes from person to person.

      I will update my article to try to clear up this confusion.

      Alison

  5. Source Nat lists there product as containing 500mg stan extract (sprouts) yielding 2mg sulforaphane. 2 caps of Jarrows is 750mg stan extract (seed though). So doing a simple ratio yields roughly 2.8mg sulphoraphane per 2 caps. Cyvex website contains some good infor on their products which are resold by Vitacost (Cyvex’s Broccoplus), which I use to obtain the glucosinolates. This product contains separate glucosinolates and sulforaphane simplyfying metabolism of SGS. I also love Swanson’s sulforaphane (Cyvex’s Broccophane). I take this thruout the day.

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