Calorie Control Weight Management Formula Aims for Safe Weight Loss Via Propolmannan Fiber, Phase 2 Complex Carb Blocker, Green Tea Fat Blocker, and Irvingia Appetite Control

In 2010, Life Extension announced a new Calorie Control Weight Management Formula product. This product combines a new fiber ingredient called propolmannan with three of the ingredients from previous successful Life Extension weight loss products including Enhanced Irvingia with Calorie Control Complex and Optimized Irvingia with Phase 3 Calorie Control Complex. The new fiber ingredient is a specially processed propolmannan fiber called LuraLean. Propolmannan is similar to the well-researched fiber glucomannan.
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VitaDigest Coupon Codes for July 2011

Two discount codes from VitaDigest run through July 15, 2011. The first is coupon code july6save6 which is good for 6.5% off on orders over $60. The second is july5Save5 for 5% off orders over $40. Shipping is free on orders over $100. Click through the banner to the right and then during checkout enter the appropriate coupon code based upon your order amount.

VitaDigest has also announced a new discount rewards point program that works out to another 1% discount for repeat customers. You can read more about it at VDRewards Points Program.

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Curcumin as a Contraceptive?

One seemingly strange observation I found while reading studies on curcumin and turmeric is that researchers have noticed curcumin has strong contraceptive properties. In 2003, a UCSD Division of Urology study cited that curcumin is an effective contraceptive at high concentrations by impairing sperm motility. That study also mentioned promising anti-HIV activity, too.

Can curcumin provide an ideal contraceptive? is another paper on similar contraceptive findings written in 2011.

The concentrations necessary for total impairment of sperm motility probably could not be reached via normal diet or oral supplementation unless many capsules of very high bioavailability curcumin were consumed.

Beyond the data published in those papers, there’s additional reason to believe that the impact of normal use of curcumin on fertility can’t be as drastic as the papers hint. For instance, consider the rapid population growth rate in India. India is one area where turmeric and curcumin are widely consumed. It has even been noted that their age-adjusted rate of Alzheimer’s Disease seems notably lower (only around 20% to 25% of Western nations by some studies) than that of populations that do not consume so much turmeric and curcumin. So if curcumin is such a potent contraceptive, then why is India’s population growing so rapidly?

The answer may lie in the widely known facts that curcumin is normally poorly absorbed and mostly stays in the digestive tract rather than reaching the blood and reproductive organs. But obviously if there is an effect with increased rates of curcumin consumption resulting in reduced rates of Alzheimer’s, some of it must be absorbed.

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Curcumin Helps Raise Low Serotonin and Dopamine in Major Depression and Other Neurological Disorders

A 2010 research paper An Overview of Curcumin in Neurological Disorders highlights how curcumin, one of the most beneficial components of the spice turmeric, may have a beneficial role to play in therapy for many neurological disorders that involve low levels of the neurotransmitters serotonin, dopamine, and norepinepherine. The researchers studied rats subjected to a model of chronic unpredictable stress to induce symptoms of major depression as measured via their neurotransmitter levels and behaviors.

In their study with rats dosed with curcumin from about 10 mg/kg body weight to 80 mg/kg body weight, they found that the animals subjected to chronic unpredictable stress had improved levels of serotonin and dopamine but their norepinepherine levels remained essentially unchanged.

As many antidepressants act upon serotonin and dopamine levels, this suggests that curcumin may have beneficial effects similar to those seen in from prescription drugs such as SSRI antidepressants. But so far, the “suicide inducing” side effects of SSRI medications have not been seen with curcumin. With further research. it may someday be confirmed that curcumin supplements could have a lower risk of dangerous side effects than SSRI medications while obtaining many of their benefits.
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High Bioavailability Curcumin Supplements from Indena, Dolcas Biotech, Verdure Sciences, and Theravalues

Curcumin is believed to be one of the most health beneficial components of the spice turmeric. One of the big challenges to effectively using turmeric as a nutritional supplement is the poor bioavailability of curcumin in its raw form. Fortunately, during the past several years a few new enhanced bioavailability versions of curcumin made their way to market. This may open up the realistic use of curcumin for conditions in which its low bioavailability outside of the digestive tract has been a major obstacle.

Possible Uses for Curcumin

There’s a rapidly growing quantity of research on curcumin, but so far there is no mainstream medical acceptance for its use. However, the range of possible benefits is very broad and includes uses in treating conditions involving inflammatory and oxidative damage to the aging body such as arthritis, neurological disorders such as Alzheimer’s Disease and major depression, several types of cancer particularly those in the digestive tract, and helping to prevent or reduce digestive tract infections such as Helicobacter pylori which is a scourge that afflicts about half the world’s population and is increasingly tied to stomach ulcers and digestive tract cancers. Some researchers even note that curcumin may have a use in combating the growing epidemic of diabetes.

Low Toxicity Risk of Curcumin

As with just about any nutritional supplement, in theory turmeric or curcumin could be toxic if consumed in truly massive dosages. But you’d probably get tired of eating them long before that happened because compared to most supplements, curcumin is not very well absorbed into the blood.
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HerbsPro Discount Coupon Codes for 5% for July 2011

HerbsPro is a nutritional supplement reseller based in Northern California. This is a new vendor for us, so we’re still evaluating them. So far, it looks like they have very competitive prices particularly for supplement fans who buy in bulk as on many products they offer increasing discounts at quantities 4, 8, and 12.

Two 5% discount codes for savings from HerbsPro run through July 31, 2011. Their “4th of July Special” coupon code DSC200523 is good for 5% off everything. DSC200549 is also good for 5% off.

Free shipping applies to orders over $89 under of 3 pounds or less weight. For heavier orders, they charge $5.95 flat rate ground shipping.

They offer a “cash back” rewards program for frequent customers that offers up to 5% back on orders over $399 (use HerbsPro discount coupon code DSC198130). After $1000 in orders, double rewards points are added. For a more complete explanation, read HerbsPro Cash Back Program.

HerbsPro reviews on Google are generally good, about 4.3 stars out of 5.

An example of a very well-priced product at HerbsPro is NOW Foods L-Proline 500mg 120 capsules amino acid supplement. In quantity 12, it costs $6.64 per bottle. With the coupons and cash back rewards program, you can save even more. Linus Pauling, the double Nobel Prize winning biochemist, believed that atherosclerosis in the circulatory system and consequent high blood pressure could be largely prevented by supplementing with high dosages of vitamin C plus L-Proline and L-Lysine amino acids. The vitamin C helps repair lesions in arterial walls and the higher concentrations of proline and lysine help to keep artery-clogging Lp(a) cholesterol to those lesions which thereby helps avoid building up atherosclerotic plaque.

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Curcumin, Thioflavin T, and Rosmarinic Acid Fight Damaging Amyloid Beta Proteins of Alzheimer’s Disease

Researchers in the past several years have identified compounds that have strong effects against factors suspected to be responsible for much of the damage to the brain seen in Alzheimer’s Disease patients. Two of these compounds, curcumin and rosmarinic acid, are found in widely used spices and herbs such as turmeric (a yellow Indian curry spice) and rosemary, sage, thyme, and mint variants such as lemon balm (Melissa officinalis) and thus herbs and spices may represent safe and relatively inexpensive sources for these compounds. A third compound, Thioflavin T, is a dye used in research and diagnostic settings.

India and Southeast Asian are areas where turmeric and curcumin are widely consumed. It has been noted that their age-adjusted rate of Alzheimer’s Disease seems notably lower (only around 20% to 25% of Western nations by some studies) than that of populations that do not consume so much turmeric and curcumin. There’s an interesting map of Alzheimer’s and dementia death rates by country that further illustrates very drastic regional differences, but unfortunately it does not appear to be age-adjusted.

Medical Research Dye Binds to Amyloid Beta Proteins

Of the three compounds, the yellowish medical dye Thioflavin T appears it may have the highest activity at aiding the body in eliminating the amyloid beta proteins believed to be a primary culprit in Alzeimer’s Disease. The dye is widely used in medical research for Alzheimer’s, but the safety and efficacy in live humans has not yet been established. How they work is not totally clear, but it appears it may involve multiple mechanisms. It is thought that the dye destabilizes amyloid beta proteins to make them fall apart, prevents clumping and abnormal folding of proteins, and “tags” amyloid beta thereby making it easier for the immune system to identify and attack these toxic substances.

The researchers at the Buck Institute for Research on Aging who studied Thioflavin T examined the effects of 10 compounds and noted that in addition to Thioflavin T, curcumin also looks particularly promising. Like Thioflavin T, curcumin was noted for its ability to improve the lifespans two groups of nematode worms (species Caenorhabditis elegans), one that was normal and another that was bred to be used as a model for Alzheimer’s Disease. Both compounds appear to “slow aging” by reducing the buildup of damaged proteins in the worms. Following these exciting findings, the researchers are moving on to studies in mice.

The study found that Thioflavin T could boost nematode lifespan by about 78%, adding about two weeks life to the worms that normally live about two to three weeks. The researchers have filed a patent on using Thioflavin T to increase lifespan.

Curcumin Counteracts Amyloid Beta Proteins

Curcumin is among the main active ingredients in the yellowish Indian spice turmeric that has been used for more than 2000 years in Indian and Chinese cuisine and medicine. The researchers who identified the mechanisms for action for Thioflavin T think that curcumin may also operate a lot like Thioflavin T. Curcumin and a compound rifamicin added about 45% to lifespan to the nematode worms in the study, not as much as the 78% for Thioflavin T but still very significant.
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Swanson Vitamins Coupon Code for 10% Discount

Use the coupon code SWAN77 (case-sensitive) at Swanson Health Products for 10% off your order. This code was working on June 27, 2011, but the expiration date is unknown.

Simply enter SWAN77 during checkout or via the Have A Promo Code? link to get your discount.

We’ve found that Swanson offers a very good selection of products at competitive prices. There are a lot of vendors on the Internet with good prices, however. One point that sets Swanson apart is their customer service and how they handle correcting the occasional order fulfillment mistake. For example, on the occasions an order is shipped a bottle short, a similar but wrong product was packed, or the contents of a bottle are missing (i.e., a shrink wrapped empty bottle), Swanson customer service consistently fixed these problems easily, politely, and quickly when contacted via email. They don’t put you through the grinder and will correct the problem at no cost to you, a nice change from the practices of some other Internet vendors who demand you ship the wrong product back — sometimes at your own cost.

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VitaDigest 6% Discount Code for June 2011

A 6% discount code from VitaDigest runs through June 30, 2011, in a promotion related to their improved website design. The discount is applied for any size order. Shipping is free on orders over $100. Click through the banner to the right and then during checkout enter the coupon code NewVitaDigest2011.

VitaDigest has also announced a new discount rewards point program that works out to another 1% discount for repeat customers. You can read more about it at VDRewards Points Program.

(ONCE AGAIN: Be sure to enter the NewVitaDigest2011 Coupon Code during checkout to get your discount!)

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Swanson Vitamins Coupon Code for Free Shipping on $49+ Orders

Use the coupon code TOPSALE6 (case-sensitive) at Swanson Health Products for free standard shipping on $49 or larger orders within the continental United States. This offers expires midnight CDT on June 27, 2011.

If you’re outside the 48 states, this discount code is good for $4.99 off your standard shipping charges.

Simply enter TOPSALE6 during checkout or via the Have A Promo Code? link to get your discount.

We’ve found that Swanson offers a very good selection of products at competitive prices. There are a lot of vendors on the Internet with good prices, however. One point that sets Swanson apart is their customer service and how they handle correcting the occasional order fulfillment mistakes. For example, on the occasions an order is shipped a bottle short, a similar but wrong product was packed, or the contents of a bottle are missing (i.e., a shrink wrapped empty bottle), Swanson customer service consistently fixed these mistakes easily, politely, and quickly when contacted via email. They don’t put you through the grinder and will correct the problem at no cost to you, a nice change from the practices of some other Internet vendors who demand you ship the wrong product back — sometimes at your own cost.

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